From the North: Follow 81 South to 380 South. Take Exit 8 (Tobyhanna) and go straight through intersection; before reaching the entrance to the Tobyhanna Army Depot, turn right onto Main Street. Go straight to firt stop sign; St. Ann's church will be visible on your left at the intersection.

From the West: Follow 81 North to 380 South. Take Exit 8 (Tobyhanna); follow directions as listed above.

From the South and East: Take 80 West to 380 North. Take Exit 8 (Route 423/Tobyhanna). Turn right at end of ramp and proceed to traffic light; go through light and at the next stop sign, turn left onto Main Street. St. Ann's will be on your right.